This paper proposes a dynamic and customizable layered serious game design framework for improving the physical and mental health of the aged after presenting the results obtained from a study with mainstream and alternative/complimentary health professionals concerning the usage of interactive games as a tool to improve both physical and mental well-being of the elderly. This study reports on the commonality of design and health factors regarding the usability of video games for the aged to ensure the elderly benefit from traditional and alternative healthcare professionals’ perspectives.